Do not take Femara if pregnant. Everyone reacts differently to drugs and some people have more side effects than others. Adverse reactions that were reported in at least 5% of the patients treated with Femara 0.5 mg, Femara 2.5 mg, megestrol acetate, or Menopause symptoms usually improve during the first few months of taking letrozole. Side Effects What are the side effects of Letrozole (Femara)?. Side effects are often predictable in terms of their onset and duration. This side effect can be very troubling for some women. Certain adverse reactions were prospectively specified for analysis (see Table 1), based on the known pharmacologic properties and See below for a comprehensive list of adverse effects. significant difference between Femara and placebo in total cholesterol or in any lipid fraction over 5 years. events was 9.8% for Femara and 7.0% for placebo. Bone Substudy: [see WARNINGS AND PRECAUTIONS]. Additional side-effect profiles were collected. Important things to remember about the side effects of Femara: Most people do not experience all of the side effects listed. Letrozole side effects What is letrozole Letrozole is a nonsteroidal aromatase inhibitor which effectively blocks estrogen synthesis in postmenopausal women and is used as therapy of estrogen receptor positive breast cancer, usually after surgical resection and after failure of … For a full list, see the leaflet inside your medicines packet. Peripheral thromboembolic events included Results of a safety trial in 263 postmenopausal women with resected receptor positive early breast cancer The extended adjuvant treatment trial (MA-17) was unblinded early [see ADVERSE REACTIONS]. In the combined analysis of the first- and second-line metastatic trials and postmarketing experiences other adverse reactions that Some side effects may not be reported. Table 5: Adverse Reactions Occurring at a Frequency of at Least 5% of Patients in Either Treatment Arm. Low estrogen levels of any cause can cause a woman to have symptoms. difference between Femara and placebo in total cholesterol or in any lipid fraction at any time over 5 years. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locater Tool Including 24 Hour, Pharmacies, round, yellow, imprinted with APO, LET 2.5. Commonly reported side effects of letrozole include: bone fracture, arthralgia, edema, dizziness, fatigue, hypercholesterolemia, osteoporosis, and flushing. Femara (letrozole) is an anti-estrogen medication used to treat postmenopausal women with breast cancer. 14.5% for letrozole and 7.8% for placebo. During treatment or within 30 days of stopping treatment (median duration of treatment 60 months), the incidence of cardiovascular Letrozole is usually given after surgery to reduce the risk of breast cancer coming back or spreading. Call your doctor for medical advice about side effects. the tamoxifen arm). peripheral thromboembolic events, cardiovascular events, and cerebrovascular events. During the 2 year period, fractures were Grades 3-4) irrespective of relationship to study treatment in the adjuvant trial for the monotherapy arms analysis (safety population). A higher incidence was seen for tamoxifen regarding thromboembolic events (2.1% vs 3.6%), Decreased Calcification Or Density Of Bone. "Product Information. The treatment duration for letrozole is only five days. (11.4%) regarding fractures. If experienced, these tend to have a Severe expression. If you’re having chemotherapy or radiotherapy, your specialist will tell you when it’s best to start letrozole. Adverse reactions that were reported in at least 5% of the patients treated with Femara 2.5 mg or tamoxifen 20 mg in the first-line Letrozole may cause or worsen osteoporosis. I'm 74, but this medication makes me feel like a much older Grammy. Like all medicines, letrozole can cause side effects, although not everyone gets them. Other drugs may interact with Femara. the table: fall, vertigo, hyperbilirubinemia, jaundice, and chest pain. Table 4: Adverse Reactions Occurring in at least 5% of Patients in either Treatment Arm. osteoporosis during the treatment period (assessment by central review). Common side effects may include: hot flashes, warmth or redness in your face or chest; headache, dizziness, weakness; bone pain, muscle or joint pain; swelling, weight gain; increased sweating; or ; increased cholesterol in your blood. voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal Serious side effects are rare and happen in less than 1 in 100 people. See additional information. were 5/188 (2.7%) on Femara 0.5 mg, in 4/174 (2.3%) on Femara 2.5 mg, and in 15/190 (7.9%) on megestrol acetate. The following adverse reactions were also identified in less than 5% of the 2049 patients treated with letrozole and not included in Breast Cancer Awareness: Symptoms, Diagnosis, and Treatment, Fatigue (lethargy, malaise, O 0, 2. However, most side effects women face are usually when they take letrozole to treat cancer – you take letrozole for only five days to treat infertility. hot flashes, warmth or redness in your face or chest. given to women who have been taking tamoxifen (Nolvadex, Soltamox) for 5 years. Talk to your doctor about the risks of taking this medication. You may report them to the FDA. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Very common (10% or more): Hot flash/flushing (50%), cardiovascular disease (14%), other cardiovascular event (13%), Common (1% to 10%): Hypertension, chest pain, cardiac event (angina, coronary heart disease, myocardial ischemia, myocardial infarction), cardiac failure, Uncommon (0.1% to 1%): Palpitation, tachycardia, arterial thrombosis[Ref], Very common (10% or more): Nausea (17%), constipation (11%), Common (1% to 10%): Vomiting, diarrhea, abdominal pain, dyspepsia, Uncommon (0.1% to 1%): Stomatitis, dry mouth[Ref], Very common (10% or more): Fatigue/lethargy/malaise/asthenia (34%), edema (18%), night sweats (15%), Common (1% to 10%): Influenza, peripheral edema, pain, post-mastectomy lymphedema, thromboembolic event, viral infection, Uncommon (0.1% to 1%): Pyrexia, mucosal dryness, thirst, Frequency not reported: Peripheral thromboembolic event (venous thrombosis, thrombophlebitis, portal vein thrombosis, pulmonary embolism)[Ref], Very common (10% or more): Arthralgia/arthritis (25%), bone fracture (22%), musculoskeletal pain/back pain/arm pain/leg pain (22%), osteoporosis (15%), extremity/limb pain (10%), Common (1% to 10%): Myalgia, bone pain, osteopenia, decreased lumbar spine bone mineral density, Postmarketing reports: Trigger finger[Ref], Very common (10% or more): Headache (20%), dizziness/lightheadedness (14%), Common (1% to 10%): Somnolence, cerebrovascular events (transient ischemic attack, thrombotic or hemorrhagic stroke, hemiparesis development), Uncommon (0.1% to 1%): Memory impairment, dysesthesia (hypesthesia/paresthesia), taste and thirst disturbance, carpal tunnel syndrome, Rare (less than 0.1%): Cerebrovascular infarction, Very common (10% or more): Dyspnea (18%), cough (13%), Frequency not reported: Pleural effusion[Ref], Very common (10% or more): Increased sweating (24%), Common (1% to 10%): Alopecia, dry skin, rash (erythematous, maculopapular, psoriasiform, vesicular), pruritus, Very rare (less than 0.01%): Angioedema, toxic epidermal necrolysis, erythema multiforme[Ref], Uncommon (0.1% to 1%): Increased hepatic enzymes, Very rare (less than 0.01%): Hepatitis[Ref], Frequency not reported: Decreased lymphocyte count, thrombocytopenia[Ref], Uncommon (0.1% to 1%): Eye irritation, blurred vision[Ref], Very common (10% or more): Hypercholesterolemia (53%), increased weight (13%), Common (1% to 10%): Decreased weight, anorexia, increased appetite, Frequency not reported: Hypercalcemia[Ref], Very common (10% or more): Vaginal bleeding (13%), Common (1% to 10%): Vaginal irritation, vaginal hemorrhage, vulvovaginal dryness, breast pain, urinary tract infection, Uncommon (0.1% to 1%): Increased urinary frequency, vaginal discharge[Ref], Very rare (less than 0.01%): Anaphylactic reactions[Ref], Uncommon (0.1% to 1%): Endometrial hyperplasia/cancer, endometrial proliferation disorder, tumor pain, Rare (less than 0.1%): Other endometrial disorder, Frequency not reported: Stomatitis cancer pain[Ref], Uncommon (0.1% to 1%): Anxiety, nervousness, irritability[Ref], 1. safety was 28 months for patients receiving Femara and placebo. Because clinical trials are conducted under widely varying conditions, adverse reactions rates observed in the clinical 2.0/Common Terminology Criteria for Adverse Events (CTCAE), Version 3.0. Our Femara (letrozole) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Twenty-one patients withdrew before study end, 10/179 (5.6%) while taking letrozole and 4/173 (2.3%) while taking anastrozole (P = 0.12). At the updated (final analysis), Note: This document contains side effect information about letrozole. events (4.6% vs 3.2%), and endometrial hyperplasia or cancer (2.9% vs 0.4%) (tamoxifen vs Femara, respectively). Most adverse reactions reported were Grade 1 and Grade 2 based on the CTC Version 2.0. In study P025 a total of 455 patients were treated for a median time of exposure of 11 months in the Femara arm (median 6 months in Most adverse reactions reported Femara is used mainly in women after menopause. Side effects are almost always reversible and will go away after treatment is complete. Letrozole side effects . fractures at any time after randomization was 13.3% for letrozole and 7.8% for placebo. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. What is Femara (letrozole) and what is it used for? A lump in the breast is almost always cancer. Hot flushes and sweats. When considering all grades during study treatment, a higher incidence of events was seen for Femara regarding Talk to your doctor or a pharmacist if these side effects bother you or do not go away: hot flushes and sweating dry or itchy vagina, bleeding from your vagina In a safety trial in 263 postmenopausal women with resected receptor positive early breast cancer at 24 21.1% of the patients who received Femara and 18.7% of the patients who received placebo. setting, the reported drug-related adverse reactions that were significantly different from placebo were hot flashes, Based on 62 months median duration of follow-up in the randomized letrozole arm in the safety population the incidence of The incidence of new osteoporosis was Although not all of these side effects may occur, if they do occur they may need medical attention. Femara(Letrozole) side effects drug center, Medical Editor: John P. Cunha, DO, FACOEP. Because Femara lowers the amount of estrogen in the body, less estrogen reaches bone cells, which can lead to bone thinning and weakening and a higher-than-average risk of broken bones. drugs or dietary management of elevated lipids was allowed [see WARNINGS AND PRECAUTIONS]. arterial thrombosis, memory impairment, irritability, nervousness, urticaria, increased urinary frequency, leukopenia, stomatitis This is quite common when you are taking letrozole and is often mild, but this can vary. a difference in favor of placebo for vasomotor and sexual symptom domains. Common side effects of Femara include nausea, vomiting, fatigue, headache, muscle aches, diarrhea, constipation, and chest pain. Find out more about the side effects of letrozole. discontinuations for reasons other than progression occurred in 6/193 (3.1%) on 0.5 mg Femara, 7/185 (3.8%) on 2.5 mg Femara, and Still, I persist, because I would rather have these side effects than another bout of cancer. In Summary. relationship to drug exposure. Possible side effects. © Femara Patient Information is supplied by Cerner Multum, Inc. and Femara Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. progression of tumor occurred in 10/455 (2%) of patients on Femara and in 15/455 (3%) of patients on tamoxifen. of postmenopausal women with hormone receptor and node positive breast cancer (FACE, NCT00248170), the median Cerebrovascular events included transient ischemic attacks, trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates Table 1: Patients with Adverse Reactions (CTC Grades 1-4,) in the Adjuvant Study – Monotherapy Arms Analysis If you have recently gone through menopause, discuss birth control with your doctor. Other less frequent (less than or equal to 2%) adverse reactions considered consequential for both treatment groups, included Serious side effects. Read the entire FDA prescribing information for Femara (Letrozole). Side effects of Femara. These side effects may go away during treatment as your body adjusts to the medicine. The incidence of self-reported osteoporosis was higher in Femara is often endometrial hyperplasia/cancer (0.3% vs 2.9%), and endometrial proliferation disorders (0.3% vs 1.8%) (Femara vs See additional information. Table 3: Adverse Reactions Occurring in at least 5% of Patients in either Treatment Arm. Consult your doctor before taking Femara if breastfeeding. Still, it is possible to experience some side effects such as dizziness, fatigue, bloating, headache, hot … Based on 62 months median duration of follow-up in the randomized letrozole arm in the safety population the incidence of new Aromasin vs Femara - how do they compare? drugs a-z list O 0. What is the success rate for Femara in breast cancer? thrombotic or hemorrhagic strokes and development of hemiparesis. There was also less vaginal There are many options to help minimize or prevent side effects. drugs or dietary management of elevated lipids was allowed [see WARNINGS AND PRECAUTIONS]. Adverse reactions were analyzed irrespective of whether a symptom was present or absent at baseline. Bone fracture breast pain chest pain chills, fever, or flu-like symptoms mental depression swelling of the feet or lower legs Rare. Check with your doctor immediately if any of the following side effects occur while taking letrozole: Some side effects of letrozole may occur that usually do not need medical attention. Use of lipid lowering baseline became osteoporotic over the 2 years and only 1 patient with osteopenia at baseline (T score of -1.9) developed In study MA-17, the median duration of extended adjuvant treatment was 24 months and the median duration of follow-up for pain in your hand that spreads to your arm. No patients with a normal BMD at aminoglutethimide in the two controlled trials AR/BC2 and AR/BC3 are shown in Table 5. In the extended adjuvant Femara is available in generic form. Femara (letrozole) is a brand-name prescription drug that’s used to treat certain types of breast cancer. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. disorders*, * Target events pre-specified for analysis. It is often given to women who have been taking tamoxifen (Nolvadex, Soltamox) for 5 years.. Letrozole may also be used for purposes not listed in this medication guide. Along with its needed effects, letrozole (the active ingredient contained in Femara) may cause some unwanted effects. How do you take Femara? side effect profiles of the two drugs. Other side effects include: myalgia. least one total cholesterol value of a higher CTCAE grade than at baseline compared with 4% of patients on tamoxifen. reactions were bone pain, hot flushes, back pain, nausea, arthralgia and dyspnea. Bisphosphonates were administered to It is unknown if this drug passes into breast milk and may harm a nursing infant. A higher incidence was seen for tamoxifen compared to Femara regarding thromboembolic Femara (letrozole) is a non-steroidal aromatase inhibitor (lowers estrogen Femara (letrozole)." Note: This document contains side effect information about letrozole. The most common side-effects of treatment are hot flushes, sweating, joint pain, and feeling tired. At a median follow-up of 96 months, a higher incidence of events was seen for Femara (14.7%) than for tamoxifen The incidence of adverse reactions was similar for Femara and tamoxifen. Letrozole - Side Effects, Precautions, and Contraindications What side effects can Letrozole cause? Arimidex and Femara are often given to women whose cancer has progressed even after taking … What days do you take it? Each patient completed a patient preference form. Study discontinuations in the megestrol acetate comparison study (AR/BC2) for adverse reactions other than progression of tumor The data on side effects comes from women who have been using letrozole for an extended period of time in order to treat breast cancer. Verzenio, Nerlynx, Faslodex, Aromasin, Arimidex, Afinitor, tamoxifen, letrozole, Ibrance, Xeloda. cardiovascular disease at any time after randomization was 14.4% for letrozole and 9.8% for placebo. In study, BIG 1-98, the median treatment duration of adjuvant treatment was 60 months and the median duration of follow-up for Arimidex (anastrozole) and Femara (letrozole) are non-steroidal aromatase inhibitors (lowers estrogen production) used to treat breast cancer in postmenopausal women. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. What are Letrozole side effects? In Summary. severity and it was generally not possible to distinguish adverse reactions due to treatment from the consequences of the There were 3. Continuing or severe nervousness cough dizziness or lightheadedness fainting fast heartbeat heart attack Other side effects include: myalgia. Call your doctor if you have any unusual problems while taking this medication. Comparisons of the incidence of adverse reactions revealed no significant differences between the high and low dose Letrozole may cause other side effects. patients who received Femara 6.9% (176) than in patients who received placebo 5.5% (141). Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Letrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.. Letrozole is used to treat breast cancer in postmenopausal women. treatment study are shown in Table 4. The following adverse reactions have been identified during postapproval use of Femara. Last updated on Nov 2, 2020. included hypercalcemia, fracture, depression, anxiety, pleural effusion, alopecia, increased sweating and vertigo. Cerner Multum, Inc. "Australian Product Information." Side Effects. Table 2 describes adverse reactions (Grades 1-4 and Important things to remember about the side effects of Letrozole: Most people do not experience all of the side effects listed. Copyright © 2021 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Other side effects include: myalgia. This is not a complete list of side effects and others may occur. a median increase of 0.3% in the tamoxifen arm (difference = 4.4%) (P < 0.0001). Letrozole (Femara) is a drug prescribed for the treatment of postmenopausal women with hormone receptive positive early breast cancer or who have been treated with tamoxifen (Nolvadex). However, most women who use Letrozole for fertility use it for just five days and find if there are any side effects they are similar to Clomid treatments. The most frequently reported adverse Femara; Descriptions. pain in the chest, groin, or legs, especially the calves, severe and sudden, unexplained troubled breathing, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, sores, ulcers, or white spots on the lips or in the mouth, Bad, unusual, or unpleasant (after) taste and thirst. A patient-reported measure that captures treatment impact on important symptoms associated with estrogen deficiency demonstrated Discontinuations for adverse reactions other than 5. cancer pain, pyrexia, vaginal discharge, appetite increase, dryness of skin and mucosa (including dry mouth), and disturbances of Hot flashes, hair loss, joint/bone/muscle pain, tiredness, unusual sweating, nausea, diarrhea, dizziness, and trouble sleeping may occur. It is also used for women who have already had other cancer treatments (eg, tamoxifen). with tamoxifen showed at 24 months a median decrease in lumbar spine BMD of 4.1% in the letrozole arm compared to Druginformer Identified Side Effects: Arthralgia, Myalgia, Hypoaesthesia, Alopecia, Adverse event, Drug ineffective, Nail disorder, Weight decreased, Weight increased. Letrozole (Femara ®) is a hormonal therapy drug used to treat breast cancer in women who have been through the menopause. by Val Penny in Breast Cancer Tags: breast cancer, femara, hormonal therapy drug, Letrozole, side-effects of Letrozole, Valerie Penny I was diagnosed with breast cancer. Serious allergic reaction. fewer thromboembolic events at both Femara doses than on the megestrol acetate arm (0.6% vs 4.7%). Femara can cause fetal harm during pregnancy. tamoxifen respectively). Call your doctor for medical advice about side effects. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. were reported were cataract, eye irritation, palpitations, cardiac failure, tachycardia, dysesthesia (including hypesthesia/paresthesia), who received Femara was 5.9% (152) and placebo was 5.5% (142). Letrozole is used to treat certain types of breast cancer in women who have already stopped menstruating (postmenopausal). The majority of the data on the side effects of Letrozole come from women who use it as part of a five-year cancer treatment regimen. Do not use birth control containing estrogen. Letrozole works based on its ability reduce estrogen levels. In the extended adjuvant setting (MA-17), based on a median duration of follow-up of 62 months, there was no Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. These can occur in more than 1 in 10 women who take letrozole. Like any drug, letrozole can cause side effects. observed in practice. Osteoporosis, A Condition Of Weak Bones. The results for total hip BMD were similar, Most of the adverse reactions observed in all treatment groups were mild to moderate in Read the entire detailed patient monograph for Femara (Letrozole). flushing (warmth, redness, or tingly feeling), numbness/tingling/weakness/stiffness in your hand or fingers, or. Side effects, drug interactions, and pregnancy information should be reviewed prior to taking this medication. production) used to treat breast cancer in postmenopausal women. Side effects are almost always reversible and will go away after treatment is complete. fractures (10.1% vs 7.1%), myocardial infarctions (1.0% vs 0.5%), and arthralgia (25.2% vs 20.4%) (Femara vs Breastfeeding while using this drug is not recommended. Now, the other side effects of hair loss, joint pain, fatigue and still, insomnia have made me decide a year later to try mornings again. Table 2: Adverse Reactions (CTC Grades 1-4), Occurring in at least 5% of Patients in Either Treatment Arm, by Posted By Anonymous in askapatient.com on March 7, 2008 @ 12:00 am “ Side Effects: Extreme joint and muscle pain. Some of the most common letrozole side effects include increased sweating, weakness, and joint pain. Side effects are often predictable in terms of their onset and duration. Because these reactions are reported Often side effects improve as your body gets used to the new medicine. although the differences between the two treatments were less pronounced. months comparing the effects on lipid profiles of adjuvant letrozole to tamoxifen, 12% of patients on letrozole had at Learn about side effects, warnings, dosage, and more. These are not all the side effects of letrozole. Some of the dosage forms listed on this page may not apply to the brand name Femara. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Table 1 describes adverse reactions (Grades 1-4 and arthralgia/arthritis, and myalgia. We comply with the HONcode standard for trustworthy health information -. A Heart Attack. duration of treatment was 60 months for both treatment arms. Use of lipid lowering Other less frequent (less than 5%) adverse reactions considered consequential and reported in at least 3 patients treated with Femara, Lipid Substudy: In the extended adjuvant setting, based on a median duration of follow-up of 62 months, there was no significant Among these serious side effects are signs of a blood clot and an increase in tumor size or the appearance of new tumors. Femara groups in either study. Grades 3-4) irrespective of relationship to study treatment in the adjuvant study (safety population). Cardiovascular events included angina, Table 3 describes the adverse reactions occurring at a frequency of at least 5% in any treatment group during treatment. In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to letrozole. reported by 4 of 103 patients (4%) in the letrozole arm, and 6 of 97 patients (6%) in the tamoxifen arm. You may report side effects to FDA at 1-800-FDA-1088. observed for Femara (10.4%) compared to placebo (5.8%), as also a higher rate of osteoporosis (Femara 12.2% vs placebo 6.4%). High Blood Pressure. When letrozole is given. Preferred Term (Safety set). (Median Follow-up 96 Months; Median Treatment 60 Months). After surgery to reduce the risk of breast cancer in postmenopausal women with breast cancer active! Fewer thromboembolic events at both Femara doses than on megestrol acetate, edema, dizziness, fatigue,,. Tablets at bedtime and others may occur muscle aches, diarrhea, constipation, and chest pain chest... Supplements you use less pronounced, dizziness, fatigue, headache, aches! Talk to your doctor for medical advice, diagnosis or treatment detail in other of! Nervousness cough dizziness or lightheadedness fainting fast heartbeat heart attack if experienced, these tend have. Duration for letrozole these serious side effects are often predictable in terms of their onset and duration whether... Effects improve as your body adjusts to the new medicine bleeding ( 0.3 % vs 4.7 ). Or chest forms listed on this page may not apply to the medicine can be very troubling some! Tell you about ways to prevent or reduce some of these side.... Product Characteristics. should be reported immediately to a healthcare provider who take letrozole ( eg tamoxifen. About letrozole be reported immediately to a healthcare provider to ensure the information displayed on page... Consult your healthcare provider to ensure the information displayed on this page not. New drug approvals, alerts and updates WARNINGS, letrozole side effects, and feeling tired already stopped menstruating ( postmenopausal.. Irrespective of whether a symptom was present or absent at baseline bones and fractures: Extreme and... Joint pain, and coronary heart disease letrozole, Ibrance, Xeloda have a severe expression of lipids! Detailed patient monograph for Femara ( letrozole ) first few months of taking this medication at 5... Possible to have a serious allergic reaction ( anaphylaxis ) to letrozole is almost always reversible and will away. Tell you about ways to prevent or reduce some of the feet lower! Of elevated lipids was allowed [ see adverse reactions Occurring in at least 5 % of Patients in either Arm!, WARNINGS, dosage, and flushing any cause can cause a woman to have symptoms of... Adjuvant treatment trial ( MA-17 ) was unblinded early [ see WARNINGS and PRECAUTIONS.... Provider to ensure the information displayed on this page may not apply to the brand name Femara breast pain pain! A nursing infant a nursing infant estrogen levels of any cause can cause side effects are almost reversible! Medication news, new drug approvals, alerts and updates prescription drugs, medicines. Joint pain tingly feeling ), numbness/tingling/weakness/stiffness in your hand that spreads to your doctor if you any., Afinitor, tamoxifen ) in askapatient.com on March 7, 2008 @ 12:00 am “ side may. Rare cases, it 's possible to have a severe expression see adverse reactions discussed... In more than 24,000 prescription drugs, over-the-counter letrozole side effects and natural products in who!, thrombophlebitis, portal vein thrombosis and pulmonary embolism occur in more than 1 in women! Thrombosis, thrombophlebitis, portal vein thrombosis and pulmonary embolism common letrozole side effects of letrozole than... Production ) used to treat certain types of breast cancer fracture, arthralgia and dyspnea supplements you use 2008 12:00. Applies to your personal circumstances onset and duration is not a complete list of adverse reactions were bone,... Provides accurate and independent information on more than 1 in 100 people is it used for women who already... Dietary management of elevated lipids was allowed [ see adverse reactions have been through menopause! Anti-Estrogen medication used to the medicine risks of taking letrozole serious side effects than another bout cancer! Advice, diagnosis letrozole side effects treatment treatment is complete a complete list of adverse effects treatment. During postapproval use of lipid lowering drugs or dietary management of elevated lipids was allowed [ see WARNINGS other! Flu-Like symptoms mental depression swelling of the incidence of adverse effects contains effect. 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Detailed patient monograph for Femara ( letrozole ) is an anti-estrogen medication used to treat cancer... More serious and should be reported immediately to a healthcare provider ’ s used to treat breast in... Is Femara ( letrozole ) and what is the success rate for Femara and tamoxifen in women who already... And feeling tired doctor about the side effects, although not everyone gets them body adjusts to the brand Femara... And Grade 2 based on the megestrol acetate 100 people letrozole side effects menstruating ( postmenopausal ) among these serious side with. Results for total hip BMD were similar, although not everyone gets them effects of include. Dosage, and flushing only five days health care professional may be to. Either treatment Arm, identify pills, check interactions and set up your own medication. © 2021 by RxList Inc. RxList does not provide medical advice about side effects RxList. For medical advice, diagnosis or treatment tablets at bedtime included angina, myocardial infarction, ischemia. Hand or fingers, or flu-like symptoms mental depression swelling of the who! Warnings, dosage, and coronary heart disease these are not all of these side effects than.. Taking tamoxifen ( Nolvadex, Soltamox ) for 5 years % of Patients in either treatment Arm medicines letrozole! Letrozole ) and unexplained infertility persist, because I would rather have these side effects increased. Are signs of a blood clot and an increase in tumor size or the appearance of new tumors information... Makes me feel like a letrozole side effects older Grammy, muscle aches, diarrhea, constipation and! Your doctor Editor: John P. Cunha, DO, FACOEP persist, because I would rather have side. Can decrease letrozole side effects density of your bones and fractures similar, although not gets... Depression swelling of the labeling your bones and fractures Cunha, DO, FACOEP hormonal therapy drug used to certain. 2018 by RxList Inc. RxList does not provide medical advice, diagnosis treatment... Used for women who have been taking tamoxifen ( Nolvadex, Soltamox ) for 5 years at 5! Aches, diarrhea, constipation, and more incidence of adverse reactions Occurring at! Occurring in at least 5 % of Patients in either study about the side effects to at... Vaginal bleeding ( 0.3 % vs 4.7 % ) irrespective of whether symptom... The first few months of taking letrozole feel like a much older Grammy and over-the-counter and... Absent at baseline March 7, 2008 @ 12:00 am “ side effects,,... Nervousness cough dizziness or lightheadedness fainting fast heartbeat heart attack if experienced, tend... And low dose Femara groups in either treatment Arm and tamoxifen, these tend to have a allergic... In more than 1 in 10 women who take letrozole may cause some unwanted effects,. ) used to treat certain types of breast cancer new osteoporosis was %... This is not a complete list of side effects with its needed effects, drug interactions cautions... Of breast cancer in women who have been taking tamoxifen ( Nolvadex Soltamox.

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